Characteristics of donor dominance and the recipient site

Hair loss being an ancient problem, hair transplant surgeries entered the world just can be said for the love the hair. Its emergence and emergency both have a huge impact to the modern civilization and every 3 out 5 men and women suffering with acute hair loss can be seen to consider a surgery.

From this point when you are one of the men and women suffering from a thinning hair density and happening to go for hair restoration treatments, of course you first activity would be to choose the right surgeon given that he should be compassionate, talented, experienced and good looking, well, clinically.

The recipient site is the bald site which needs extra hair, hair loss can happen to both men and women, but men are more affected with it than women. And in some ways, men’s hair loss causes differ than that of women and also the surgery more detailed way, the graft dissection. We will come to that in a while.

For the meantime, when you are going for a hair restoration surgery, your donor site is the place which still bears hair after all the hair loss scarcity. In men, hair loss occurs usually as a case of Androgenic alopecia or male pattern baldness wherein they lose hair in either of two patterned ways, from either the temples or sides of the forehead or the center of the head. Both ways the end a small patch of hair remains in the back of the scalp and above the ears and this works as the donor site.

In women this is case trick as is a woman’s reputation, their hair loss symptoms do not follow any pattern and fall off just like that, dispersedly in this case the donor site is determined with densitometry and other diagnosis to abide by the right decision of the proper donor site.

Donor dominance - Baldness is often a hereditary, genetic and hormonal affect to the body. And in a hair restoration treatment, a donor dominance denotes the fact that the chosen donor hair that have not been lost as opposed to the recipient site, will when transplanted to the recipient site won’t fall of and will continue to live and function as it had in its home. In the way it will dominate the recipient and the androgenic reactions that has caused the hair loss in that area. Donor dominance

Donor Dominance, in hereditary baldness, hair maintains the characteristics of where it was taken from, regardless of where in the scalp it is placed. This is because the genetic predisposition for hair loss resides in the follicle, rather than in the scalp.

So how is it determined that the remaining hair in the scalp is actually donor dominant and not androgen affected and in the line to fall off in the future?

Single-donor dominance is observed in the majority of patients following double-unit cord blood transplantation (dCBT); however, the biological basis for this outcome is poorly understood it works in the following assessment:

To investigate the possible influence of specific cell lineages on dominance in dCBT, flow cytometry assessment for CD34(+), CD14(+), CD20(+), CD3(-)CD56(+), CD3(+)CD56(+) (natural killer), and T cell subsets (CD4(+), CD8(+), memory, naïve, and regulatory) was performed on individual units. Subsets were calculated as infused viable cells per kilogram of recipient actual weight. Sixty patients who underwent dCBT were included in the final analysis. Higher CD3 (+) cell dose was statistically concordant with the dominant unit in 72% of cases (P = .0006). Further T cell subset analyses showed that dominance was correlated more with the naive CD8 (+) cell subset (71% concordance; P = .009) than with the naive CD4 (+) cell subset (61% concordance; P = .19). These data indicate that a greater total CD3 (+) cell dose, particularly of naïve CD3 (+) CD8(+) T cells, may play an important role in determining single-donor dominance after dCBT.